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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS13C All Species: 12.73
Human Site: S1966 Identified Species: 35
UniProt: Q709C8 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q709C8 NP_001018098.1 3753 422390 S1966 G V A F H N D S F Q L G E L R
Chimpanzee Pan troglodytes XP_510458 3836 431033 S2049 G V A F H N D S F Q L G E L R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851912 3629 408076 S1965 K L S F H N D S F R L G E L R
Cat Felis silvestris
Mouse Mus musculus Q8BX70 3748 420070 S1961 R L S F H N D S F R L G E L T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511058 3801 426177 H2004 T L S S R S D H L R F G E L R
Chicken Gallus gallus XP_001233000 3758 422392 E1967 P L L S L H N E K L C L G E L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922767 3699 412330 E1943 S Q P C V H E E K S C L G E F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192977 2470 271032 D836 P E I I L V A D S S T K D T N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07878 3144 357831 M1509 M T M D S P K M I L A M D Y L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.9 N.A. 87 N.A. 86.4 N.A. N.A. 77.2 68.7 N.A. 59.6 N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 97.4 N.A. 92 N.A. 93.3 N.A. N.A. 87.6 82.9 N.A. 76.8 N.A. N.A. N.A. N.A. 41
P-Site Identity: 100 100 N.A. 73.3 N.A. 66.6 N.A. N.A. 33.3 0 N.A. 0 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 N.A. 93.3 N.A. 86.6 N.A. N.A. 60 20 N.A. 13.3 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 23 0 0 0 12 0 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 12 0 0 0 0 0 0 23 0 0 0 0 % C
% Asp: 0 0 0 12 0 0 56 12 0 0 0 0 23 0 0 % D
% Glu: 0 12 0 0 0 0 12 23 0 0 0 0 56 23 0 % E
% Phe: 0 0 0 45 0 0 0 0 45 0 12 0 0 0 12 % F
% Gly: 23 0 0 0 0 0 0 0 0 0 0 56 23 0 0 % G
% His: 0 0 0 0 45 23 0 12 0 0 0 0 0 0 0 % H
% Ile: 0 0 12 12 0 0 0 0 12 0 0 0 0 0 0 % I
% Lys: 12 0 0 0 0 0 12 0 23 0 0 12 0 0 0 % K
% Leu: 0 45 12 0 23 0 0 0 12 23 45 23 0 56 23 % L
% Met: 12 0 12 0 0 0 0 12 0 0 0 12 0 0 0 % M
% Asn: 0 0 0 0 0 45 12 0 0 0 0 0 0 0 12 % N
% Pro: 23 0 12 0 0 12 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 12 0 0 0 0 0 0 0 23 0 0 0 0 0 % Q
% Arg: 12 0 0 0 12 0 0 0 0 34 0 0 0 0 45 % R
% Ser: 12 0 34 23 12 12 0 45 12 23 0 0 0 0 0 % S
% Thr: 12 12 0 0 0 0 0 0 0 0 12 0 0 12 12 % T
% Val: 0 23 0 0 12 12 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _